Endocrine Abstracts

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

Introduction: The prevalence of thyroid diseases increase with age. Mostly, they are undiagnosed. The lack of overt clinical appearance of hypo-hyperthyroidism in elder people increases the need for an attentive clinician to suspect and investigate for their presence. Thyroid dysfunctions, especially subclinics, are more frequently seen in older populations, have been linked to increased morbidity and mortality. Therefore, elderly people should evaluate in terms of thyroid fun...

Introduction: Adrenal myelolipoma is a rare benign tumour composed of mature adipose tissue and hematopoietic tissue. Most lesions are small and asymptomatic, discovered incidentally during autopsy or on imaging studies performed for other reasons. Usually small and asymptomatic, but has been reported to present with symptoms such as abdominal pain resulting from tumour bulk, necrosis or spontaneous retroperitoneal haemorrhage.Case 54-year old woman who ...

Introduction: Fahr’s disease is a rare, neurological disorder characterized by abnormal calcified deposits in basal ganglia. The clinical characteristics are various and usually appears such as disfunction of the affected areas. According to our knowledge, no case of Fahr’s disease together with pregnancy has been described in the literature until now. The objective of this case report was to describe the clinical course of this rare condition in pregnancy.<p cla...

Introduction: Pseudohypoparathyroidism is characterised by hypocalcaemia, hyperphosphataemia, increased serum parathyroid hormone values and insensitivity to the biological activity of parathyroid hormone. Pseudohypoparathyroidism is often associated with a characteristic phenotype known as Albright’s hereditary osteodystrophy. This case was reported in order to remind pseudohypoparathyroidism in patients with hypocalcemic seizures.Case report: We d...

Introduction: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder characterised by delayed or absent sexual maturation and infertility associated with inappropriately low gonadotropin and sex steroid levels. Insulin resistance (IR) is defined as an impaired biologic response to both endogenous and exogenous insulin. IR is a common precursor to the development of glucose intolerance, including diabetes, hypertension, and cardiovascular disease. Dyslipidaemia, apol...

Introduction: Since bariatric surgery is considered to be a more effective treatment modality for morbid obesity, a growing number of patients have been referred to endocrinology clinics in order to exclude an underlying cause. Routine preoperative testing to screen Cushing’s syndrome (CS) or hypothyroidism is still debatable. The aim of this study is to evaluate the accuracy of routine testing in preoperative endocrinological evaluation.Methods/des...

Aim: Although there are some studies regarding the effects of cigarette smoking on serum total cortisol (STC) and salivary cortisol (SaC) levels, the results are still challenging. For this purpose, we aimed to determine the effects of cigarette smoking on STC and/ or SaC levels in a small group of healthy volunteers.Study design: 15 (five female and ten male) cigarette smoker with the mean age of 39.47±14.27, and 15 age and gender matched non-smoke...

Introduction: Although, vitamin D (vit D) mainly regulates calcium and phosphate metabolisms, its deficiency may also contribute to the development of some carcinomas, autoimmune, and cardiac diseases. Vit D deficiency has been defined to correlate with increased autoimmune disease such as type 1 diabetes mellitus, rheumatoid arthritis, autoimmune thyroid diseases (AITD). Previous studies suggested that patients with AITD had lower vit D levels when compared with healthy contr...

Introduction: Traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), stroke and cerebrovascular disease (CVD) are identified as risk factors for hypopituitarism. However, the mechanisms and the risk factors for the hypothalamo-pituitary dysfunction due to TBI, SAH, stroke and CVD are still unclear (1,2,3). Hypoxia, hypoxemia, neuroinflammation, autoimmunity could have impact in the pathogenesis (4). In patients with serious ventricular arrhythmias who need resuscitation,...